2.Definition: an important question that is in dispute and must be settled
"The issue could be settled by requiring public education for everyone", "Politicians never discuss the real issues"
3.Definition: an opening that permits escape or release
"He blocked the way out", "The canyon had only one issue"
Related Noun(s):exit, outlet
4.Definition: one of a series published periodically
"She found an old issue of the magazine in her dentist's waiting room"
7.Definition: the act of issuing printed materials
8.Definition: the act of providing an item for general use or for official purposes (usually in quantity)
"A new issue of stamps", "The last issue of penicillin was over a month ago"
9.Definition: the becoming visible
Related Noun(s):emergence, egress
10.Definition: the immediate descendants of a person
"She was the mother of many offspring", "He died without issue"
Related Noun(s):offspring, progeny